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| Registros recuperados: 16 | |
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| Oliveira,Ana Cláudia de; Bortotti,Ana Clara; Nunes,Nathália Neves; Bacha,Ibrahin A.H. El; Parise,Edison Roberto. |
| Introduction:A population-based survey conducted in Brazilian capital cities found that only 16% of the population had ever been tested for hepatitis C. These data suggest that much of the Brazilian population with HCV infection remains undiagnosed. The distribution of age ranges at diagnosis and its association with the degree of hepatitis C are still unknown in Brazilian patients.Material and methods:Patients with HCV infection, diagnosed by HCV RNA (Amplicor-HCV, Roche), were included in the study. Patients with HBV or HIV coinfection, autoimmune diseases, or alcohol intake > 20 g/day were excluded. HCV genotyping was performed by sequence analysis, and viral load by quantitative RT-PCR (Amplicor, Roche). The METAVIR classification was used to assess... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic hepatitis C; Age at diagnosis; Hepatic fibrosis. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500507 |
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| Sabbatani,Sergio; Giuliani,Ruggero; Manfredi,Roberto. |
| The elevated frequency of chronic hepatitis C virus (HCV) infection found among prison inmates, and the availability of improved pharmacological cure for this potentially life-threatening disorder, make investigations conducted in this somewhat neglected area very relevant, since only a few, open-label experiences have been reported till now. In the metropolitan prison of Bologna (Italy), HCV seroprevalence was found to be over 31% in 2003, so that a pilot feasibility study based on treatment with pegylated interferon plus ribavirin was initiated, after careful counseling carried out by a joint commission of health care personnel of the correctional facility and infectious diseases consultants. Thirty-nine patients were enrolled, and despite expected... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic hepatitis C; Pegylated interferon; Ribavirin; Management; Inmates; Prison. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400012 |
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| Focaccia,R.; Baraldo,D.C.M.; Ferraz,M.L.G.; Martinelli,A.L.C.; Carrilho,F.J.; Gonçales Jr.,F.L.; Pedroso,M.L.A.; Coelho,H.S.M.; Lacerda,M.A.; Brandão,C.E.; Mattos,A.A.; Lira,L.G.C.; Zamin Jr.,I.; Pinheiro,J.O.P.; Tovo,C.V.; Both,C.T.; Soares,J.A.S.; Dittrich,S.. |
| Hepatitis C virus (HCV) infection is a serious public health problem, since 80% to 85% of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma. Considering that the response of hepatitis C patients to combination therapy with interferon and ribavirin depends on HCV characteristics as well as on host features, we made a retrospective analysis of demographic and anthropometrical data and HCV genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil. The medical records of 4,996 patients were reviewed, 81% from public and 19% from private institutions. Patients' median age was 46 years, and there was a higher prevalence of male (62%) and white patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HCV; Chronic hepatitis C; Genotype; Body weight; Brazil. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500003 |
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| Abdallah,N; Morsi,M; Hamed,N; Abdel Aziz,H. |
| The most reliable determination of severity and prognosis in chronic viral hepatitis is the histological staging of the disease, which comprises an invasive procedure and is often not well accepted by patients. The search for alternative non-invasive methods is mandatory especially in follow-ups after initial assessment by biopsy. The aim of this study was to evaluate the role of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in patients under interferon alpha therapy whether responsive or non-responsive to therapy. Thirty chronic hepatitis C patients (CHC) under combined therapy of interferon-α with ribavirin, whether responsive or non-responsive, were included in the study as well as ten healthy controls. Serum... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ICAM-1; VCAM-1; Interferon; Ribavirin; Chronic hepatitis C. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300010 |
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| Prado,Kleber; Patzina,Rosely; Bergamaschi,Denise; Focaccia,Roberto. |
| Chronic hepatitis C is often a progressive, fibrotic disease that can lead to cirrhosis and other complications. The recommended therapy is a combination of interferon and ribavirin. Besides its antiviral action, interferon is considered to have antifibrotic activity. We examined the outcome of hepatic fibrosis and inflammation in chronic hepatitis C patients who were non-responders to interferon. We made a case series, retrospective study, based on revision of medical records and reassessment of liver biopsies. For inclusion, patients should have been treated with interferon alone or combined with ribavirin, with no virological response (non responders and relapsers) and had a liver biopsy before and after treatment. Histological evaluation included:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic hepatitis C; Fibrosis; Interferon-alfa; Ribavirin; Treatment result. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500004 |
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| Oliveira,Isabela S.; Cabral,Milena S.; Jesus,Larissa S.; Paraná,Raymundo; Atta,Ajax M.; Atta,Maria Luiza B. Sousa. |
| Hepatitis C virus (HCV) infects B-lymphocytes, provokes cellular dysfunction and causes lymphoproliferative diseases such as cryoglobulinemia and non-Hodgkin's B-cell lymphoma. In the present study, we investigated the serum levels of kappa and lambda free light chains (FLC) of immunoglobulins and the kappa/lambda FLC ratio in Brazilian patients with chronic HCV infection and cryoglobulinemia. We also analyzed the immunochemical composition of the cryoglobulins in these patients. Twenty-eight cryoglobulinemic HCV patients composed the target group, while 37 HCV patients without cryoglobulinemia were included as controls. The median levels of kappa and lambda FLC were higher in patients with cryoglobulinemia compared to controls (p = 0.001 and p = 0.003,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic hepatitis C; Cryoglobulin; Free light chain; B-cell polyclonal activation. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600638 |
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| Registros recuperados: 16 | |
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